Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal traff...

Full description

Bibliographic Details
Main Authors:	Julian Budzinski, Simone Maschauer, Hiroyuki Kobayashi, Pierre Couvineau, Hannah Vogt, Peter Gmeiner, Anna Roggenhofer, Olaf Prante, Michel Bouvier, Dorothee Weikert
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02574-4

Similar Items

Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors
by: Simone Maschauer, et al.
Published: (2017-03-01)

In Vivo Monitoring of the Antiangiogenic Effect of Neurotensin Receptor-Mediated Radiotherapy by Small-Animal Positron Emission Tomography: A Pilot Study
by: Simone Maschauer, et al.
Published: (2014-04-01)

Development of Bivalent Ligands Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Heterodimer
by: Reinecke, Bethany A
Published: (2019)

In Vitro and In Vivo Characterization of Selected Fluorine-18 Labeled Radioligands for PET Imaging of the Dopamine D3 Receptor
by: Natascha Nebel, et al.
Published: (2016-08-01)

Revising Endosomal Trafficking under Insulin Receptor Activation
by: Maria J. Iraburu, et al.
Published: (2021-06-01)

The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome
by: Carlene Petes, et al.
Published: (2017-09-01)

Biochemical studies on the neurotensin receptor
by: Mills, Ann
Published: (1988)

Fluorescent ligands for dopamine D2/D3 receptors
by: Anni Allikalt, et al.
Published: (2020-12-01)

Imaging Neurotensin Receptor in Prostate Cancer With Cu-Labeled Neurotensin Analogs
by: Huaifu Deng MD, et al.
Published: (2017-08-01)

[18F]Fluorophenylazocarboxylates: Design and Synthesis of Potential Radioligands for Dopamine D3 and μ‑Opioid Receptor
by: Natascha Nebel, et al.
Published: (2017-12-01)

Development of Bivalent Ligands Targeting the Putative CCR5-MOR Heterodimer
by: Raborg, Thomas
Published: (2014)

Functionally selective activation of the dopamine receptor D2 is mirrored by the protein expression profiles
by: Deborah Wenk, et al.
Published: (2021-02-01)

Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental Dopamine Neurons that Coordinates Energy Balance
by: Hillary L. Woodworth, et al.
Published: (2017-08-01)

Presynaptic action of neurotensin on dopamine release through inhibition of D<sub>2 </sub>receptor function
by: Trudeau Louis-Eric, et al.
Published: (2009-08-01)

Receptor sorting within endosomal trafficking pathway is facilitated by dynamic actin filaments.
by: Emiko Ohashi, et al.
Published: (2011-01-01)

Hierarchical Sorting And Trafficking Of β - 2 Adrenergic Receptors Via Endosomal Microdomains
by: Vistein, Rachel
Published: (2014)

Modeling the Heterodimer Interfaces of Melatonin Receptors
by: Lap Hang Tse, et al.
Published: (2021-10-01)

Neurotensin and its receptors in the control of glucose homeostasis
by: Jean eMazella, et al.
Published: (2012-11-01)

Dynamics of endosomal trafficking
by: Dawson, Jonathan Edward
Published: (2012)

Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
by: Terri M Driessen, et al.
Published: (2014-01-01)

Role of LRRK2 in the regulation of dopamine receptor trafficking.
by: Mauro Rassu, et al.
Published: (2017-01-01)

Functional aspects of the interactions between neurotensin and dopamine in the brain
by: Ford, A. P. D. W.
Published: (1988)

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: A Short Review
by: Simone Maschauer, et al.
Published: (2014-01-01)

Biophysical studies of the G-protein coupled neurotensin receptor
by: Hadingham, Timothy Charles
Published: (2006)

Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes
by: Maria Rödiger, et al.
Published: (2018-02-01)

Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body
by: R. De Caro, et al.
Published: (2009-09-01)

Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body
by: A. Porzionato, et al.
Published: (2009-09-01)

A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer
by: Shengyang Qiu, et al.
Published: (2017-01-01)

Neurotensin receptor 1 signaling promotes pancreatic cancer progression
by: Kei Takahashi, et al.
Published: (2021-01-01)

Ventral midbrain NTS1 receptors mediate conditioned reward induced by the neurotensin analogue, D-Tyr[11]neurotensin
by: Khalil eRouibi, et al.
Published: (2015-12-01)

Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking.
by: Komla Sobo, et al.
Published: (2007-09-01)

Bivalent ligands for the Î²â‚‚ adrenergic receptor
by: Nikbin, Nikzad
Published: (2003)

A Marine Analgesic Peptide, Contulakin-G, and Neurotensin are Distinct Agonists for Neurotensin Receptors: Uncovering Structural Determinants of Desensitization Properties
by: Hee-Kyoung eLee, et al.
Published: (2015-02-01)

Amino terminal domains of the NMDA receptor are organized as local heterodimers.
by: Chia-Hsueh Lee, et al.
Published: (2011-04-01)

The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review
by: Stella Nikolaou, et al.
Published: (2020-04-01)

Effects of selective neurotensin receptor antagonists on responding for brain stimulation reward
by: Del Vecchio, Anne-Sophie
Published: (1999)

Mechanisms of AMPA Receptor Endosomal Sorting
by: Gabrielle T. Parkinson, et al.
Published: (2018-12-01)

Structure-guided development of heterodimer-selective GPCR ligands
by: Harald Hübner, et al.
Published: (2016-07-01)

Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.
by: Brittany Ebersole, et al.
Published: (2015-01-01)

Virus Control of Trafficking from Sorting Endosomes
by: Sebastian Zeltzer, et al.
Published: (2018-07-01)

Cannot write session to /tmp/vufind_sessions/sess_6k54ajv2gpuagu42bcmn9c93e1