Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer
Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal traff...
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| Format: | Article |
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Nature Publishing Group
2021-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02574-4 |
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doaj-c19eeb6e87c441afa774ebbb7ead711b2021-09-12T11:12:08ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111310.1038/s42003-021-02574-4Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimerJulian Budzinski0Simone Maschauer1Hiroyuki Kobayashi2Pierre Couvineau3Hannah Vogt4Peter Gmeiner5Anna Roggenhofer6Olaf Prante7Michel Bouvier8Dorothee Weikert9Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, Université de MontréalDepartment of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, Université de MontréalDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, Université de MontréalDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-NürnbergBudzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal trafficking of D3R, suggesting a potential role for dimerization in vivo.https://doi.org/10.1038/s42003-021-02574-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Julian Budzinski Simone Maschauer Hiroyuki Kobayashi Pierre Couvineau Hannah Vogt Peter Gmeiner Anna Roggenhofer Olaf Prante Michel Bouvier Dorothee Weikert |
| spellingShingle |
Julian Budzinski Simone Maschauer Hiroyuki Kobayashi Pierre Couvineau Hannah Vogt Peter Gmeiner Anna Roggenhofer Olaf Prante Michel Bouvier Dorothee Weikert Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer Communications Biology |
| author_facet |
Julian Budzinski Simone Maschauer Hiroyuki Kobayashi Pierre Couvineau Hannah Vogt Peter Gmeiner Anna Roggenhofer Olaf Prante Michel Bouvier Dorothee Weikert |
| author_sort |
Julian Budzinski |
| title |
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer |
| title_short |
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer |
| title_full |
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer |
| title_fullStr |
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer |
| title_full_unstemmed |
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer |
| title_sort |
bivalent ligands promote endosomal trafficking of the dopamine d3 receptor-neurotensin receptor 1 heterodimer |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-09-01 |
| description |
Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal trafficking of D3R, suggesting a potential role for dimerization in vivo. |
| url |
https://doi.org/10.1038/s42003-021-02574-4 |
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