Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress

Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress

Introduction: Our previous studies demonstrated that dantrolene, a ryanodine receptor stabilizer, prevents endoplasmic reticulum (ER) stress in the heart. ER stress is a strong mediator of impaired lipid metabolism in the liver, thereby contributing to fatty liver disease. In this study, we investig...

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Bibliographic Details
Main Authors: Masaki Tamitani, Takeshi Yamamoto, Naoki Yamamoto, Koichi Fujisawa, Shinji Tanaka, Yoshihide Nakamura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Taro Takami, Shigeki Kobayashi, Isao Sakaida, Masafumi Yano
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Non-alcoholic fatty liver disease
Dantrolene
Palmitic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820300960

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