EFFECT OF CHEMOTHERAPY ON PHILADELPHIA CHROMOSOME IN CHRONIC MYELOID LEUKEMIA (CML) PATIENTS

• Main Authors: Chandra Bhusan Jha, k Kucheria, V P Chaudhary
• Format: Article
• Language: English
• Published: Nepal Medical Association 2003-01-01
• Series: Journal of Nepal Medical Association
• Online Access: http://jnma.com.np/jnma/index.php/jnma/article/view/745

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder as a result of neoplastic transformation of the primitive hemopoetic cells. It is well known that the Philadelphia chormosome (ph) is a specific abnormality found in 90% of CML patients. It has been reported that interferon has better effect on disease control and prognosis. Cytogenetic analysis of ph chromosome plays very important role in the prognosis and monitoring of therapy. In this present study 35 diagnosed patients of CML were considered, which included untreated patients of various age groups (2-62yrs). The cases were refered from haematology clinic of All India Institute of Medical Sciences (AIIMS). Out of 35 patients only 13 patients were available after six month of therapy for follow-up cytogenetic analysis. Out of 13 patient, 2 were ph negative, 8 were 100% ph positive and 3 were ph positive mosaic before therapy. Of the 3 mosaic patients, 2 remained unchanged after therapy and one patient became 100% ph negative. Though in general significant reduction in ph% by interferon therapy was seen but minority patients showed complete cytogenetic remission Key Words: Chronic myeloid leukemia, chemotherapy, Philadelphia chromosome.