Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy.

Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy.

Histone deacetylase inhibitors (HDACi) can induce human immunodeficiency virus (HIV) transcription from the HIV long terminal repeat (LTR). However, ex vivo and in vivo responses to HDACi are variable and the activity of HDACi in cells other than T-cells have not been well characterised. Here, we de...

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Bibliographic Details
Main Authors: Hao K Lu, Lachlan R Gray, Fiona Wightman, Paula Ellenberg, Gabriela Khoury, Wan-Jung Cheng, Talia M Mota, Steve Wesselingh, Paul R Gorry, Paul U Cameron, Melissa J Churchill, Sharon R Lewin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4237424?pdf=render

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