A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism.
ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB (vesicle-associated membrane protein (VAMP)-associated membrane protein B)/ALS8). We have established a fly model of ALS8 using the corresponding mutation in Drosophila VAPB (dVAP33A) and examined the effects of this...
Main Authors: | Anuradha Ratnaparkhi, George M Lawless, Felix E Schweizer, Peyman Golshani, George R Jackson |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-06-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2390852?pdf=render |
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