A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism.

A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism.

ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB (vesicle-associated membrane protein (VAMP)-associated membrane protein B)/ALS8). We have established a fly model of ALS8 using the corresponding mutation in Drosophila VAPB (dVAP33A) and examined the effects of this...

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Bibliographic Details
Main Authors: Anuradha Ratnaparkhi, George M Lawless, Felix E Schweizer, Peyman Golshani, George R Jackson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2390852?pdf=render

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http://europepmc.org/articles/PMC2390852?pdf=render

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