The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methods

18F-Fluorodeoxyglucose has optimal characteristics for use in nuclear medicine and is a priority among radiopharmaceuticals for the diagnosis of cancer by positron emission tomography (PET). 18F-Fluorodeoxyglucose has the longest half-life with the lowest energy of radiation, it allows to obtain PET...

Full description

Bibliographic Details
Main Authors: V. V. Kachaniuk, V. V. Trokhymchuk, S. Y. Sarychev
Format: Article
Language:Ukrainian
Published: The State Expert Center of the Ministry of Health of Ukraine 2018-08-01
Series:Фармацевтичний журнал
Subjects:
Online Access:https://pharmj.org.ua/index.php/journal/article/view/51/48
id doaj-c1645998207a4f328addf89394da5673
record_format Article
spelling doaj-c1645998207a4f328addf89394da56732020-11-25T00:45:04ZukrThe State Expert Center of the Ministry of Health of UkraineФармацевтичний журнал0367-30572617-96282018-08-011515810.32352/0367-3057.1.17.07The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methodsV. V. Kachaniuk0V. V. Trokhymchuk1S. Y. Sarychev2Ukrainian Military Medical Academy, KyivNational Medical Academy of Postgraduate Education, KyivClinical Hospital «Feofania» the State Administration, Kyiv18F-Fluorodeoxyglucose has optimal characteristics for use in nuclear medicine and is a priority among radiopharmaceuticals for the diagnosis of cancer by positron emission tomography (PET). 18F-Fluorodeoxyglucose has the longest half-life with the lowest energy of radiation, it allows to obtain PET images of high contrast at low dose loading on the patient. Low energy positron radiation provides high spatial resolution of PET images. However, the half-life of 18F-Fluorodeoxyglucose is large enough to allow the transportation of radiopharmaceuticals from the centralized production site to diagnostic centers with PET scanners (the so-called PET satellite concept), and to extend the time limits of PET research and synthesis of radiopharmaceuticals [1]. The study is the development of technology and quality control methods to ensure quality at all stages of the production of radiopharmaceuticals 18F-Fluorodeoxyglucose, injection. There was justified 18F-Fluorodeoxyglucose production technology and quality control at all stages of production, based on complex research in the department producing radiopharmaceuticals Ukrainian Center of radiosurgery consisting Clinical Hospital «Feofaniya». Object of study – 18F-Fluorodeoxyglucose, injection, injection is used in nuclear medicine for PET diagnosis of cancer. We used the biopharmaceutical and pharmaceutical methods. For the first time based pharmaceutical research was the rational technology of diagnostic radiopharmaceuticals 18F-Fluorodeoxyglucose, injection for use in PET diagnosis of cancer patients. Methods of controlling drug 18F-Fluorodeoxyglucose, injection according monographs of the State Pharmacopoeia of Ukraine. On the basis of the analysis developed by established methods of control performance specifications and shelf life of radiopharmaceuticals 18F-Fluorodeoxyglucose, injection.https://pharmj.org.ua/index.php/journal/article/view/51/48Fludeoxyglucoseradiopharmaceuticaltechnologylaboratory analysis methodsolution
collection DOAJ
language Ukrainian
format Article
sources DOAJ
author V. V. Kachaniuk
V. V. Trokhymchuk
S. Y. Sarychev
spellingShingle V. V. Kachaniuk
V. V. Trokhymchuk
S. Y. Sarychev
The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methods
Фармацевтичний журнал
Fludeoxyglucose
radiopharmaceutical
technology
laboratory analysis method
solution
author_facet V. V. Kachaniuk
V. V. Trokhymchuk
S. Y. Sarychev
author_sort V. V. Kachaniuk
title The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methods
title_short The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methods
title_full The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methods
title_fullStr The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methods
title_full_unstemmed The development of technology of Fludeoxyglucose (18F) for injection, laboratory analysis methods
title_sort development of technology of fludeoxyglucose (18f) for injection, laboratory analysis methods
publisher The State Expert Center of the Ministry of Health of Ukraine
series Фармацевтичний журнал
issn 0367-3057
2617-9628
publishDate 2018-08-01
description 18F-Fluorodeoxyglucose has optimal characteristics for use in nuclear medicine and is a priority among radiopharmaceuticals for the diagnosis of cancer by positron emission tomography (PET). 18F-Fluorodeoxyglucose has the longest half-life with the lowest energy of radiation, it allows to obtain PET images of high contrast at low dose loading on the patient. Low energy positron radiation provides high spatial resolution of PET images. However, the half-life of 18F-Fluorodeoxyglucose is large enough to allow the transportation of radiopharmaceuticals from the centralized production site to diagnostic centers with PET scanners (the so-called PET satellite concept), and to extend the time limits of PET research and synthesis of radiopharmaceuticals [1]. The study is the development of technology and quality control methods to ensure quality at all stages of the production of radiopharmaceuticals 18F-Fluorodeoxyglucose, injection. There was justified 18F-Fluorodeoxyglucose production technology and quality control at all stages of production, based on complex research in the department producing radiopharmaceuticals Ukrainian Center of radiosurgery consisting Clinical Hospital «Feofaniya». Object of study – 18F-Fluorodeoxyglucose, injection, injection is used in nuclear medicine for PET diagnosis of cancer. We used the biopharmaceutical and pharmaceutical methods. For the first time based pharmaceutical research was the rational technology of diagnostic radiopharmaceuticals 18F-Fluorodeoxyglucose, injection for use in PET diagnosis of cancer patients. Methods of controlling drug 18F-Fluorodeoxyglucose, injection according monographs of the State Pharmacopoeia of Ukraine. On the basis of the analysis developed by established methods of control performance specifications and shelf life of radiopharmaceuticals 18F-Fluorodeoxyglucose, injection.
topic Fludeoxyglucose
radiopharmaceutical
technology
laboratory analysis method
solution
url https://pharmj.org.ua/index.php/journal/article/view/51/48
work_keys_str_mv AT vvkachaniuk thedevelopmentoftechnologyoffludeoxyglucose18fforinjectionlaboratoryanalysismethods
AT vvtrokhymchuk thedevelopmentoftechnologyoffludeoxyglucose18fforinjectionlaboratoryanalysismethods
AT sysarychev thedevelopmentoftechnologyoffludeoxyglucose18fforinjectionlaboratoryanalysismethods
AT vvkachaniuk developmentoftechnologyoffludeoxyglucose18fforinjectionlaboratoryanalysismethods
AT vvtrokhymchuk developmentoftechnologyoffludeoxyglucose18fforinjectionlaboratoryanalysismethods
AT sysarychev developmentoftechnologyoffludeoxyglucose18fforinjectionlaboratoryanalysismethods
_version_ 1725271481771884544