The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage

The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage

Pseudodesmin A (PSD) is a cyclic lipodepsipeptide produced by Pseudomonas that kills certain bacteria at MIC1/2 in the single micromolar range, probably by permeabilizing their cellular membranes. Synthetic PSD variants, where the native decanoic (C10) acyl chain is varied in length from C4 to C8 an...

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Bibliographic Details
Main Authors: Jessica Steigenberger, Yentl Verleysen, Niels Geudens, José C. Martins, Heiko Heerklotz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Microbiology
Subjects:
cyclic lipodepsipeptides
membrane-permeabilizing
structure-function relationship
Pseudomonas
pseudodesmin A
liposome leakage
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.669709/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.669709/full

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