Graft-Induced Plasticity in the Mammalian Host CNS

Graft-Induced Plasticity in the Mammalian Host CNS

In this review we trace back the history of an idea that takes a new approach in restorative neurotransplantation by focusing on the “multifaceted dialogue” between graft and host and assigns a central role to graft-evoked host plasticity. In several experimental examples ranging from the transfer o...

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Main Authors: Jitka Ourednik, Václav Ourednik
Format: Article
Language:English
Published: SAGE Publishing 2004-04-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/000000004783983963
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spelling doaj-c15ba16c6b094f408dbb1ee05e0bde322020-11-25T03:03:22ZengSAGE PublishingCell Transplantation0963-68971555-38922004-04-011310.3727/000000004783983963Graft-Induced Plasticity in the Mammalian Host CNSJitka Ourednik0Václav Ourednik1Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011In this review we trace back the history of an idea that takes a new approach in restorative neurotransplantation by focusing on the “multifaceted dialogue” between graft and host and assigns a central role to graft-evoked host plasticity. In several experimental examples ranging from the transfer of solid fetal tissue grafts into mechanical cortical injuries to deposits of neural stem cells into hemisectioned spinal cord, MPTP-damaged substantia nigra or mutant cerebella supportive evidence is provided for the hypothesis, that in many CNS disorders regeneration of the host CNS can be achieved by taking advantage of the inherent capacity of neural grafts to induce protective and restorative mechanisms within the host. This principle might once allow us to spare even complex circuitry from neurodegeneration.https://doi.org/10.3727/000000004783983963
collection DOAJ
language English
format Article
sources DOAJ
author Jitka Ourednik
Václav Ourednik
spellingShingle Jitka Ourednik
Václav Ourednik
Graft-Induced Plasticity in the Mammalian Host CNS
Cell Transplantation
author_facet Jitka Ourednik
Václav Ourednik
author_sort Jitka Ourednik
title Graft-Induced Plasticity in the Mammalian Host CNS
title_short Graft-Induced Plasticity in the Mammalian Host CNS
title_full Graft-Induced Plasticity in the Mammalian Host CNS
title_fullStr Graft-Induced Plasticity in the Mammalian Host CNS
title_full_unstemmed Graft-Induced Plasticity in the Mammalian Host CNS
title_sort graft-induced plasticity in the mammalian host cns
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 2004-04-01
description In this review we trace back the history of an idea that takes a new approach in restorative neurotransplantation by focusing on the “multifaceted dialogue” between graft and host and assigns a central role to graft-evoked host plasticity. In several experimental examples ranging from the transfer of solid fetal tissue grafts into mechanical cortical injuries to deposits of neural stem cells into hemisectioned spinal cord, MPTP-damaged substantia nigra or mutant cerebella supportive evidence is provided for the hypothesis, that in many CNS disorders regeneration of the host CNS can be achieved by taking advantage of the inherent capacity of neural grafts to induce protective and restorative mechanisms within the host. This principle might once allow us to spare even complex circuitry from neurodegeneration.
url https://doi.org/10.3727/000000004783983963
work_keys_str_mv AT jitkaourednik graftinducedplasticityinthemammalianhostcns
AT vaclavourednik graftinducedplasticityinthemammalianhostcns
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