In vitro and In silico Evaluation of Structurally Diverse Benzyl pyrrolidin-3-ol Analogues as Apoptotic Agents via Caspase Activation

In vitro and In silico Evaluation of Structurally Diverse Benzyl pyrrolidin-3-ol Analogues as Apoptotic Agents via Caspase Activation

The activation of caspases is central to apoptotic process in living systems. Defects in apoptosis have been implicated with carcinogenesis. Need to develop smart agents capable of inducing apoptosis in tumor cells is obvious. With this motive, diversity oriented synthesis of 1-benzylpyrrolidin-3-ol...

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Bibliographic Details
Main Authors: Tahira Naqvi, Asif Amin, Shujat Ali, Mohsin Yousuf Lone, Nadeem Bashir, Shafi U. Khan, Thet T. Htare, Masood Ahmad Rizvi
Format: Article
Language:English
Published: Slovenian Chemical Society 2021-09-01
Series:Acta Chimica Slovenica
Subjects:
benzyl pyrrolidin-3-ol
caspase-3
molecular dynamic simulations
bioavailability
ugi reaction
biophysical methods
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/6684

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