Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the Orai1 Ca2+channel.
Bibliographic Details
| Main Authors: |
Tongde Wu,
Julianne Huang,
Patrick J. Moore,
Michael S. Little,
William G. Walton,
Robert C. Fellner,
Neil E. Alexis,
Y. Peter Di,
Matthew R. Redinbo,
Stephen L. Tilley,
Robert Tarran |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14118
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