Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme

Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme

Abstract Background Hypertension and/or myocardial infarction are common causes of heart failure in Type 2 diabetes. Progression to heart failure is usually preceded by ventricular dysfunction, linked to matrix metalloproteinase (MMP) mediated extracellular matrix changes. We hypothesise that the mi...

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Bibliographic Details
Main Authors: Chris Watson, J. Paul Spiers, Max Waterstone, Adam Russell-Hallinan, Joseph Gallagher, Kenneth McDonald, Cristin Ryan, John Gilmer, Mark Ledwidge
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cardiovascular Disorders
Subjects:
MMP-9
Diabetes
Hypertension
Myocardial infarction
Imaging
Heart failure
Online Access:https://doi.org/10.1186/s12872-021-01860-7

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