The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

Abstract Background Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare coding variant in the PLCG2 gene (rs72824905, p.P522R...

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Bibliographic Details
Main Authors: Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Macrophage
Microglia
Knock-in mouse model
PLCG2
Online Access:http://link.springer.com/article/10.1186/s13024-020-00402-7

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