Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular and all-cause mortality and treating Mg deficiency may help prevent cardiovascular disease. In this review, we discuss the po...

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Main Authors: Man Liu, Samuel C. Dudley
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/9/10/907
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spelling doaj-c11fcb17775d46648c2e237f3a01455f2020-11-25T03:53:44ZengMDPI AGAntioxidants2076-39212020-09-01990790710.3390/antiox9100907Magnesium, Oxidative Stress, Inflammation, and Cardiovascular DiseaseMan Liu0Samuel C. Dudley1Division of Cardiology, Department of Medicine, the Lillehei Heart Institute, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USADivision of Cardiology, Department of Medicine, the Lillehei Heart Institute, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USAHypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular and all-cause mortality and treating Mg deficiency may help prevent cardiovascular disease. In this review, we discuss the possible mechanisms by which Mg deficiency plays detrimental roles in cardiovascular diseases and review the results of clinical trials of Mg supplementation for heart failure, arrhythmias and other cardiovascular diseases.https://www.mdpi.com/2076-3921/9/10/907antioxidantinflammationmitochondriaarrhythmiasheart failure with preserved ejection fractionheart failure with reduced ejection fraction
collection DOAJ
language English
format Article
sources DOAJ
author Man Liu
Samuel C. Dudley
spellingShingle Man Liu
Samuel C. Dudley
Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease
Antioxidants
antioxidant
inflammation
mitochondria
arrhythmias
heart failure with preserved ejection fraction
heart failure with reduced ejection fraction
author_facet Man Liu
Samuel C. Dudley
author_sort Man Liu
title Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease
title_short Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease
title_full Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease
title_fullStr Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease
title_full_unstemmed Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease
title_sort magnesium, oxidative stress, inflammation, and cardiovascular disease
publisher MDPI AG
series Antioxidants
issn 2076-3921
publishDate 2020-09-01
description Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular and all-cause mortality and treating Mg deficiency may help prevent cardiovascular disease. In this review, we discuss the possible mechanisms by which Mg deficiency plays detrimental roles in cardiovascular diseases and review the results of clinical trials of Mg supplementation for heart failure, arrhythmias and other cardiovascular diseases.
topic antioxidant
inflammation
mitochondria
arrhythmias
heart failure with preserved ejection fraction
heart failure with reduced ejection fraction
url https://www.mdpi.com/2076-3921/9/10/907
work_keys_str_mv AT manliu magnesiumoxidativestressinflammationandcardiovasculardisease
AT samuelcdudley magnesiumoxidativestressinflammationandcardiovasculardisease
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