Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages

Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages

Scavenger receptor BI (SR-BI), an HDL receptor, plays a key role in reverse cholesterol transport. In mice, disruption of SR-BI results in hypersensitivity to lipopolysaccharide (LPS) and bacteria-induced septic shock due to adrenal insufficiency and abnormal hepatic pathogen clearance. In this stud...

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Bibliographic Details
Main Authors: Lei Cai, Zhen Wang, Jason M. Meyer, Ailing Ji, Deneys R. van der Westhuyzen
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Journal of Lipid Research
Subjects:
scavenger receptor
inflammation
lipopolysaccharide
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418516

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