Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors

Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors

Molecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in m...

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Main Authors: Devid Damiani, André M. Goffinet, Arthur Alberts, Fadel Tissir
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13509
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spelling doaj-c11a93950379466dbfd85bd0c23e59552021-05-11T10:36:57ZengNature Publishing GroupNature Communications2041-17232016-11-017111210.1038/ncomms13509Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitorsDevid Damiani0André M. Goffinet1Arthur Alberts2Fadel Tissir3Developmental Neurobiology Unit, Université catholique de Louvain, Institute of NeuroscienceDevelopmental Neurobiology Unit, Université catholique de Louvain, Institute of NeuroscienceLaboratory of Cell Structure and Signal Integration, Van Andel Research InstituteDevelopmental Neurobiology Unit, Université catholique de Louvain, Institute of NeuroscienceMolecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in microcephaly in mice.https://doi.org/10.1038/ncomms13509
collection DOAJ
language English
format Article
sources DOAJ
author Devid Damiani
André M. Goffinet
Arthur Alberts
Fadel Tissir
spellingShingle Devid Damiani
André M. Goffinet
Arthur Alberts
Fadel Tissir
Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
Nature Communications
author_facet Devid Damiani
André M. Goffinet
Arthur Alberts
Fadel Tissir
author_sort Devid Damiani
title Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_short Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_full Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_fullStr Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_full_unstemmed Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_sort lack of diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-11-01
description Molecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in microcephaly in mice.
url https://doi.org/10.1038/ncomms13509
work_keys_str_mv AT deviddamiani lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors
AT andremgoffinet lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors
AT arthuralberts lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors
AT fadeltissir lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors
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