Asymmetric catalysis in synthetic strategies for chiral benzothiazepines

Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers. This review provides a concise overview for the asymmetric s...

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Main Authors:	Haifeng Wang, Shuangxi Gu, Qiongjiao Yan, Li Ding, Fen-Er Chen
Format:	Article
Language:	English
Published:	KeAi Communications Co. Ltd. 2020-06-01
Series:	Green Synthesis and Catalysis
Subjects:	Chiral benzothiazepine Asymmetric catalysis Metal catalysis Enzymatic catalysis Organic catalysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666554920300053

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spelling	doaj-c1199107cd424e51afa558be582898f52021-10-05T04:21:23ZengKeAi Communications Co. Ltd.Green Synthesis and Catalysis2666-55492020-06-01111225Asymmetric catalysis in synthetic strategies for chiral benzothiazepinesHaifeng Wang0Shuangxi Gu1Qiongjiao Yan2Li Ding3Fen-Er Chen4School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, ChinaSchool of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, ChinaSchool of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, ChinaEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, ChinaSchool of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs, Shanghai 200433, China; Corresponding author. Engineering Center of Catalysis and synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers. This review provides a concise overview for the asymmetric synthesis of chiral benzothiazepine derivatives, focusing on advances in asymmetric catalysis, including metal catalysis, small-molecule organocatalysis and enzymatic catalysis. The catalytic asymmetric reactions, involving asymmetric epoxidation, reduction, dihydroxylation, hydrogenation, aldol reaction and other sulfa-Michael addition, have emerged as powerful strategies for the rapid construction of chiral benzothiazepine through single or multistep reactions. The booming asymmetric synthetic methodology affords us instructive clues for the highly efficient preparation of chiral benzothiazepines, facilitating their large-scale preparation and diversity-oriented synthesis.http://www.sciencedirect.com/science/article/pii/S2666554920300053Chiral benzothiazepineAsymmetric catalysisMetal catalysisEnzymatic catalysisOrganic catalysis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Haifeng Wang Shuangxi Gu Qiongjiao Yan Li Ding Fen-Er Chen
spellingShingle	Haifeng Wang Shuangxi Gu Qiongjiao Yan Li Ding Fen-Er Chen Asymmetric catalysis in synthetic strategies for chiral benzothiazepines Green Synthesis and Catalysis Chiral benzothiazepine Asymmetric catalysis Metal catalysis Enzymatic catalysis Organic catalysis
author_facet	Haifeng Wang Shuangxi Gu Qiongjiao Yan Li Ding Fen-Er Chen
author_sort	Haifeng Wang
title	Asymmetric catalysis in synthetic strategies for chiral benzothiazepines
title_short	Asymmetric catalysis in synthetic strategies for chiral benzothiazepines
title_full	Asymmetric catalysis in synthetic strategies for chiral benzothiazepines
title_fullStr	Asymmetric catalysis in synthetic strategies for chiral benzothiazepines
title_full_unstemmed	Asymmetric catalysis in synthetic strategies for chiral benzothiazepines
title_sort	asymmetric catalysis in synthetic strategies for chiral benzothiazepines
publisher	KeAi Communications Co. Ltd.
series	Green Synthesis and Catalysis
issn	2666-5549
publishDate	2020-06-01
description	Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers. This review provides a concise overview for the asymmetric synthesis of chiral benzothiazepine derivatives, focusing on advances in asymmetric catalysis, including metal catalysis, small-molecule organocatalysis and enzymatic catalysis. The catalytic asymmetric reactions, involving asymmetric epoxidation, reduction, dihydroxylation, hydrogenation, aldol reaction and other sulfa-Michael addition, have emerged as powerful strategies for the rapid construction of chiral benzothiazepine through single or multistep reactions. The booming asymmetric synthetic methodology affords us instructive clues for the highly efficient preparation of chiral benzothiazepines, facilitating their large-scale preparation and diversity-oriented synthesis.
topic	Chiral benzothiazepine Asymmetric catalysis Metal catalysis Enzymatic catalysis Organic catalysis
url	http://www.sciencedirect.com/science/article/pii/S2666554920300053
work_keys_str_mv	AT haifengwang asymmetriccatalysisinsyntheticstrategiesforchiralbenzothiazepines AT shuangxigu asymmetriccatalysisinsyntheticstrategiesforchiralbenzothiazepines AT qiongjiaoyan asymmetriccatalysisinsyntheticstrategiesforchiralbenzothiazepines AT liding asymmetriccatalysisinsyntheticstrategiesforchiralbenzothiazepines AT fenerchen asymmetriccatalysisinsyntheticstrategiesforchiralbenzothiazepines
_version_	1716843606581444608

Asymmetric catalysis in synthetic strategies for chiral benzothiazepines

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