Endocrine complications in patients with major β-thalassemia

• Main Authors: Parastoo Rostami, Gisoo Hatami, Afshin Shirkani
• Format: Article
• Language: English
• Published: Bushehr University of Medical Sciences 2011-11-01
• Series: Iranian South Medical Journal
• Subjects: βthalassemia major; hypoparathyroidism; short stature; hypogonadism; hypothyroidism
• Online Access: http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-241&slc_lang=en&sid=1

Background: Endocrine complications in patients with major β –thalassemia related to iron overload that the most important cause of mortality and morbidity in this patients.This study evaluate prevalence of endocrine complications in major β -thalassemia. Methods: Sixty patients with major β- thalassemia enrolled in this study. Results: We assessed 60 patients, including 27 men and 33 female disorders with major β- thalassemia by age range (10-44 years-old). 26.8% of patients didn’t have any endocrine disorders, 23.5% of patients one disorder and 48.7% have more than two. The most common complications of endocrinewere: hypogonadism (66.7%), short stature (45%), hypoparathyroidism (21.7%), diabet mellitus (18.3%), impaired glucose tolerance (6.7%), overt hypothyroidism (1.65%), subclinical hypothyroidism (1.65%). Conclusion: High prevalence of endocrine complications found in this study may emphasize regular endocrine assessment. In thalassemic patients especially in patients over the age of 10 years old.