A long-lasting emerging epidemic of anthroponotic cutaneous leishmaniasis in southeastern Iran: population movement and peri-urban settlements as a major risk factor

• Main Authors: Taiebeh Karimi, Iraj Sharifi, Mohammad Reza Aflatoonian, Behnaz Aflatoonian, Mohammad Ali Mohammadi, Ehsan Salarkia, Zahra Babaei, Farzaneh Zarinkar, Fatemeh Sharifi, Nima Hatami, Ahmad Khosravi, Arsalan Eskandari, Elyas Solimani, Mehdi Shafiee, Masoumeh Mozaffari, Amireh Heshmatkhah, Rezvan Amiri, Saeideh Farajzadeh, Alireza Kyhani, Abbas Aghaei Afshar, Abdollah Jafarzadeh, Mehdi Bamorovat
• Format: Article
• Language: English
• Published: BMC 2021-02-01
• Series: Parasites & Vectors
• Subjects: Population movement; Cutaneous leishmaniasis epidemic; PCR-RFLP; Phylogenetic analysis; Iran
• Online Access: https://doi.org/10.1186/s13071-021-04619-3

Abstract Background Epidemics of cutaneous leishmaniasis (CL) are occurring more frequently and spreading faster and farther than before in many areas of the world. The present study aimed to assess a long-lasting emerging epidemic (2005–2019) of 5532 cases with anthroponotic CL (ACL) in peri-urban areas of Kerman city in southeastern Iran. Methods This descriptive-analytical study was carried out for 15 years in Kerman province, southeastern Iran. The data were passively obtained through the health surveillance system and the Kerman Leishmaniasis Research Center. Every subject was diagnosed using direct smear microscopy. The representative causative agent was further examined by ITS1-PCR, PCR-RFLP, 7SL RNA gene sequencing and phylogenetic analyses. For each subject, a case report form designating demographic and clinical data was recorded. Results A different pattern of ACL incidence was found in peri-urban areas compared to that in the city of Kerman. The incidence rate of ACL cases has significantly increased (P < 0.001) from 2005 to 2016 in new settlements with a gradual decline after that. The overall average risk of contracting the disease was 7.6 times higher in peri-urban areas compared to Kerman city, an old endemic focus. All isolates consisting of six variants were confirmed to be Leishmania tropica. The overall pattern of the ACL infection indicates that the etiological agent of ACL is propagated and transmitted by the bite of female Phlebotomus sergenti sandflies from person to person from dissimilar clones as reflected by the complexity of the migrants’ backgrounds in the province. Conclusions The movement of populations and establishment of new settlements in peri-urban areas close to endemic areas are major risk factors for and are directly linked to CL. The underlying factors of this emerging ACL epidemic caused by L. tropica were disasters and droughts, among others. A robust commitment to a multilateral approach is crucial to make improvements in this area. This will require decisive coordinated actions through all governmental factions and non-governmental organizations. Furthermore, active and passive case detection strategies, early diagnosis, and effective treatment could help control the disease.