Heterozygous P32/C1QBP/HABP1 Polymorphism rs56014026 Reduces Mitochondrial Oxidative Phosphorylation and Is Expressed in Low-grade Colorectal Carcinomas

Heterozygous P32/C1QBP/HABP1 Polymorphism rs56014026 Reduces Mitochondrial Oxidative Phosphorylation and Is Expressed in Low-grade Colorectal Carcinomas

Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 (C1QBP/gC1qR) is essential for mitochondrial protein translation and thus indispensable for OXPHOS activity. It is ubiquitously expressed and directed to the mitoc...

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Bibliographic Details
Main Authors: Annika Raschdorf, Annika Sünderhauf, Kerstin Skibbe, Berhane Ghebrehiwet, Ellinor I. Peerschke, Christian Sina, Stefanie Derer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
metabolism
mitochondria
OXPHOS
p32
single nucleotide polymorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.631592/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.631592/full

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