Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma

Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is the 10th most frequent human malignancy and is thus a global burden. Despite some progress in diagnosis and therapy, patients’ overall survival rate, between 40 and 55%, has stagnated over the last four decades. Since the tumor node metastasis (TNM) system is n...

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Bibliographic Details
Main Authors: Alexander W. Eckert, Matthias Kappler, Ivo Große, Claudia Wickenhauser, Barbara Seliger
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
oral squamous cell carcinoma
metabolism
tumor microenvironment
hypoxia
prognosis
Online Access:https://www.mdpi.com/1422-0067/21/17/6083

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