Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to I...

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Main Authors: Jan Baxa, Milan Hromádka, Jakub Šedivý, Lucie Štěpánková, Jiří Moláček, Bernhard Schmidt, Thomas Flohr, Jiří Ferda
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/105629
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spelling doaj-c0c532a989de48129f932764e206464d2020-11-24T23:30:59ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/105629105629Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic PatientsJan Baxa0Milan Hromádka1Jakub Šedivý2Lucie Štěpánková3Jiří Moláček4Bernhard Schmidt5Thomas Flohr6Jiří Ferda7Department of Imaging Methods, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech RepublicDepartment of Cardiology, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech RepublicDepartment of Cardiology, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech RepublicDepartment of Internal Medicine, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech RepublicDepartment of Surgery, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech RepublicSiemens Healthcare, CT Physics and Applications Development, Siemensstrasse 1, 91301 Forchheim, GermanySiemens Healthcare, CT Physics and Applications Development, Siemensstrasse 1, 91301 Forchheim, GermanyDepartment of Imaging Methods, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech RepublicThe prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p=0.002; per-vessel: specificity 95 versus 75%, p=0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40–70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.http://dx.doi.org/10.1155/2015/105629
collection DOAJ
language English
format Article
sources DOAJ
author Jan Baxa
Milan Hromádka
Jakub Šedivý
Lucie Štěpánková
Jiří Moláček
Bernhard Schmidt
Thomas Flohr
Jiří Ferda
spellingShingle Jan Baxa
Milan Hromádka
Jakub Šedivý
Lucie Štěpánková
Jiří Moláček
Bernhard Schmidt
Thomas Flohr
Jiří Ferda
Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
BioMed Research International
author_facet Jan Baxa
Milan Hromádka
Jakub Šedivý
Lucie Štěpánková
Jiří Moláček
Bernhard Schmidt
Thomas Flohr
Jiří Ferda
author_sort Jan Baxa
title Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_short Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_full Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_fullStr Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_full_unstemmed Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_sort regadenoson-stress dynamic myocardial perfusion improves diagnostic performance of ct angiography in assessment of intermediate coronary artery stenosis in asymptomatic patients
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p=0.002; per-vessel: specificity 95 versus 75%, p=0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40–70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.
url http://dx.doi.org/10.1155/2015/105629
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