| Summary: | <p>Abstract</p> <p>Background</p> <p>The follicle cells of the <it>Drosophila </it>egg chamber provide an excellent model in which to study modulation of the cell cycle. During mid-oogenesis, the follicle cells undergo a variation of the cell cycle, endocycle, in which the cells replicate their DNA, but do not go through mitosis. Previously, we showed that Notch signaling is required for the mitotic-to-endocycle transition, through downregulating String/Cdc25, and Dacapo/p21 and upregulating Fizzy-related/Cdh1.</p> <p>Results</p> <p>In this paper, we show that Notch signaling is modulated by Shaggy and temporally induced by the ligand Delta, at the mitotic-to-endocycle transition. In addition, a downstream target of Notch, <it>tramtrack</it>, acts at the mitotic-to-endocycle transition. We also demonstrate that the JNK pathway is required to promote mitosis prior to the transition, independent of the cell cycle components acted on by the Notch pathway.</p> <p>Conclusion</p> <p>This work reveals new insights into the regulation of Notch-dependent mitotic-to-endocycle switch.</p>
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