Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease

Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease

Abstract Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta concomitant with Lewy body formation in affected brain areas. The detailed pathogenic mechanisms unde...

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Bibliographic Details
Main Authors: Zhi Dong Zhou, Thevapriya Selvaratnam, Ji Chao Tristan Lee, Yin Xia Chao, Eng-King Tan
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Translational Neurodegeneration
Subjects:
Molecular targets
Neuron degeneration
Parkinson’s disease
Protein aggregation
Protein translation
Proteostasis
Online Access:http://link.springer.com/article/10.1186/s40035-019-0145-0

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