Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst

Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst

5-acetyl-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones were synthesized in good to excellent by one-pot three-component Biginelli condensation in the presence of ammonium salt [Et3NH][HSO4] as an inexpensive and green catalyst under solvent-free conditions. High yields, short reaction time, easy w...

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Main Authors: Behjat Pouramiri, Raziye Fayazi, Esmat Tavakolinejad Kermani
Format: Article
Language:English
Published: Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 2018-02-01
Series:Iranian Journal of Chemistry & Chemical Engineering
Subjects:
biginelli reaction
3,4-dihydropyrimidin-2(1h)-one
triethylammonium hydrogen sulfate
ionic liquid
Online Access:http://www.ijcce.ac.ir/article_26367_686a10e47412ac46344da3f0bb66b943.pdf
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spelling doaj-c0942ae5026840b1a46116ae7df7bb012020-11-25T03:55:01ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering 1021-99861021-99862018-02-0137115916726367Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green CatalystBehjat Pouramiri0Raziye Fayazi1Esmat Tavakolinejad Kermani2Department of Chemistry, Shahid Bahonar University of Kerman, Kerman 76169, I.R. IRANDepartment of Chemistry, Shahid Bahonar University of Kerman, Kerman 76169, I.R. IRANDepartment of Chemistry, Shahid Bahonar University of Kerman, Kerman 76169, I.R. IRAN5-acetyl-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones were synthesized in good to excellent by one-pot three-component Biginelli condensation in the presence of ammonium salt [Et3NH][HSO4] as an inexpensive and green catalyst under solvent-free conditions. High yields, short reaction time, easy work-up, a green environment which requires no toxic organic solvents and reusability of the catalyst are the advantages of this procedure. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing and electron releasing groups) was applied successfully, and corresponding products were obtained in good to excellent yields without any by-product. In addition, this catalyst was stable during the reaction process and could also be reused several times with consistent activity.http://www.ijcce.ac.ir/article_26367_686a10e47412ac46344da3f0bb66b943.pdfbiginelli reaction3,4-dihydropyrimidin-2(1h)-onetriethylammonium hydrogen sulfateionic liquid
collection DOAJ
language English
format Article
sources DOAJ
author Behjat Pouramiri
Raziye Fayazi
Esmat Tavakolinejad Kermani
spellingShingle Behjat Pouramiri
Raziye Fayazi
Esmat Tavakolinejad Kermani
Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst
Iranian Journal of Chemistry & Chemical Engineering
biginelli reaction
3,4-dihydropyrimidin-2(1h)-one
triethylammonium hydrogen sulfate
ionic liquid
author_facet Behjat Pouramiri
Raziye Fayazi
Esmat Tavakolinejad Kermani
author_sort Behjat Pouramiri
title Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst
title_short Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst
title_full Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst
title_fullStr Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst
title_full_unstemmed Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2(1H)-one Derivatives Using [Et3NH][HSO4] as Environmentally Benign and Green Catalyst
title_sort facile and rapid synthesis of 3,4-dihydropyrimidin-2(1h)-one derivatives using [et3nh][hso4] as environmentally benign and green catalyst
publisher Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
series Iranian Journal of Chemistry & Chemical Engineering
issn 1021-9986
1021-9986
publishDate 2018-02-01
description 5-acetyl-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones were synthesized in good to excellent by one-pot three-component Biginelli condensation in the presence of ammonium salt [Et3NH][HSO4] as an inexpensive and green catalyst under solvent-free conditions. High yields, short reaction time, easy work-up, a green environment which requires no toxic organic solvents and reusability of the catalyst are the advantages of this procedure. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing and electron releasing groups) was applied successfully, and corresponding products were obtained in good to excellent yields without any by-product. In addition, this catalyst was stable during the reaction process and could also be reused several times with consistent activity.
topic biginelli reaction
3,4-dihydropyrimidin-2(1h)-one
triethylammonium hydrogen sulfate
ionic liquid
url http://www.ijcce.ac.ir/article_26367_686a10e47412ac46344da3f0bb66b943.pdf
work_keys_str_mv AT behjatpouramiri facileandrapidsynthesisof34dihydropyrimidin21honederivativesusinget3nhhso4asenvironmentallybenignandgreencatalyst
AT raziyefayazi facileandrapidsynthesisof34dihydropyrimidin21honederivativesusinget3nhhso4asenvironmentallybenignandgreencatalyst
AT esmattavakolinejadkermani facileandrapidsynthesisof34dihydropyrimidin21honederivativesusinget3nhhso4asenvironmentallybenignandgreencatalyst
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