Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and Citrus reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of nobiletin and the associated potential mechanisms in ACHN and Caki-2 renal carcinoma cells. A CCK-8 assay...

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Bibliographic Details
Main Authors: Di Wei, Geng Zhang, Zheng Zhu, Yu Zheng, Fei Yan, Chongxian Pan, Zhiyong Wang, Xian Li, Fuli Wang, Ping Meng, Wanxiang Zheng, Zhao Yan, Dongsheng Zhai, Zifan Lu, Jianlin Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
nobiletin
renal carcinoma cells
SRC
AKT
STAT3
YY1AP1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00690/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00690/full

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