Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects

Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects

ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works descri...

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Bibliographic Details
Main Authors: GILDA NEVES, MILENE BORSOI, CAMILA B. ANTONIO, MARIANA A. PRANKE, ANDRESA H. BETTI, STELA M.K. RATES
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2017-08-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
antidepressant-like effect
immobility behavior
locomotor activity
memory negative symptoms
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017005018105&lng=en&tlng=en

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