Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.

Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.

DNA double-strand breaks trigger the production of locus-derived siRNAs in fruit flies, human cells and plants. At least in flies, their biogenesis depends on active transcription running towards the break. Since siRNAs derive from a double-stranded RNA precursor, a major question is how broken DNA...

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Bibliographic Details
Main Authors: Karin Merk, Marco Breinig, Romy Böttcher, Stefan Krebs, Helmut Blum, Michael Boutros, Klaus Förstemann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5495518?pdf=render

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