Montelukast reduces seizures in pentylenetetrazol-kindled mice

Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study,...

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Bibliographic Details
Main Authors: J. Fleck, F.R. Temp, J.R. Marafiga, A.C. Jesse, L.H. Milanesi, L.M. Rambo, C.F. Mello
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2016-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
PTZ
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400602&lng=en&tlng=en