Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.

Thoracic aortic calcification (TAC) is tightly linked to pathological atherosclerosis and associated with certain cardiovascular diseases. While diabetes mellitus (DM) is known as a coronary heart disease equivalent, we examined the presence of TAC across the dysglycemic spectrum of diabetes mellitu...

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Main Authors: Jui-Peng Tsai, Richard Kuo, Jing-Yi Sun, Chun-Ho Yun, Kuo-Tze Sung, Chuan-Chuan Liu, Jen-Yuan Kuo, Chung-Lieh Hung, Tung-Hsin Wu, Jiun-Lu Lin, Ta-Chuan Hung, Chia-Yuan Liu, Charles Jia-Yin Hou, Hung-I Yeh, Hiram G Bezerra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207089
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spelling doaj-c06529a0f4514b4c947ce40be303c4202021-03-03T20:59:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01141e020708910.1371/journal.pone.0207089Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.Jui-Peng TsaiRichard KuoJing-Yi SunChun-Ho YunKuo-Tze SungChuan-Chuan LiuJen-Yuan KuoChung-Lieh HungTung-Hsin WuJiun-Lu LinTa-Chuan HungChia-Yuan LiuCharles Jia-Yin HouHung-I YehHiram G BezerraThoracic aortic calcification (TAC) is tightly linked to pathological atherosclerosis and associated with certain cardiovascular diseases. While diabetes mellitus (DM) is known as a coronary heart disease equivalent, we examined the presence of TAC across the dysglycemic spectrum of diabetes mellitus (DM). We consecutively studied 3003 asymptomatic ethnic Asians underwent annual cardiovacular health survey, and further categorized them into: 1) 1760 normo-glycemic, 2) 968 pre-diabetic, and 3) 274 overt DM based on dysglycemic indices and medical histories. Several TAC parameters were assessed using non-contrast multi-detector computed tomography (MDCT), and related to dysglycemic indices or diabetes mellitus status. A remarkably graded increases of adjusted total TAC calcium burden, volume and density were seen across Non-diabetes, Pre-diabetes, and diabetes mellitus categories and positively correlated with all dysglycemic profiles (all p<0.001). Multi-variate logistic and linear regression models demonstrated independent associations between greater TAC density and all dysglycemic indices (Coef: 2.5, 1.4, 6.8 for fasting, postprandial sugar and HbA1c) and diabetes mellitus status (all p<0.05). Furthermore, Receiver-operating characteristic curves (ROC) showed fasting sugar and postprandial sugar set at 103mg/dL and 111mg/dL, separately, with HbA1c set at 5.8% all predict the presence of aortic calcification. Dysglycemic status, even without overt diabetes mellitus, were tighly linked to subclinical, pathological thoracic aortic calcification.https://doi.org/10.1371/journal.pone.0207089
collection DOAJ
language English
format Article
sources DOAJ
author Jui-Peng Tsai
Richard Kuo
Jing-Yi Sun
Chun-Ho Yun
Kuo-Tze Sung
Chuan-Chuan Liu
Jen-Yuan Kuo
Chung-Lieh Hung
Tung-Hsin Wu
Jiun-Lu Lin
Ta-Chuan Hung
Chia-Yuan Liu
Charles Jia-Yin Hou
Hung-I Yeh
Hiram G Bezerra
spellingShingle Jui-Peng Tsai
Richard Kuo
Jing-Yi Sun
Chun-Ho Yun
Kuo-Tze Sung
Chuan-Chuan Liu
Jen-Yuan Kuo
Chung-Lieh Hung
Tung-Hsin Wu
Jiun-Lu Lin
Ta-Chuan Hung
Chia-Yuan Liu
Charles Jia-Yin Hou
Hung-I Yeh
Hiram G Bezerra
Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.
PLoS ONE
author_facet Jui-Peng Tsai
Richard Kuo
Jing-Yi Sun
Chun-Ho Yun
Kuo-Tze Sung
Chuan-Chuan Liu
Jen-Yuan Kuo
Chung-Lieh Hung
Tung-Hsin Wu
Jiun-Lu Lin
Ta-Chuan Hung
Chia-Yuan Liu
Charles Jia-Yin Hou
Hung-I Yeh
Hiram G Bezerra
author_sort Jui-Peng Tsai
title Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.
title_short Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.
title_full Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.
title_fullStr Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.
title_full_unstemmed Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.
title_sort thoracic aortic calcification across the clinical dysglycemic continuum in a large asian population free of cardiovascular symptoms.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2019-01-01
description Thoracic aortic calcification (TAC) is tightly linked to pathological atherosclerosis and associated with certain cardiovascular diseases. While diabetes mellitus (DM) is known as a coronary heart disease equivalent, we examined the presence of TAC across the dysglycemic spectrum of diabetes mellitus (DM). We consecutively studied 3003 asymptomatic ethnic Asians underwent annual cardiovacular health survey, and further categorized them into: 1) 1760 normo-glycemic, 2) 968 pre-diabetic, and 3) 274 overt DM based on dysglycemic indices and medical histories. Several TAC parameters were assessed using non-contrast multi-detector computed tomography (MDCT), and related to dysglycemic indices or diabetes mellitus status. A remarkably graded increases of adjusted total TAC calcium burden, volume and density were seen across Non-diabetes, Pre-diabetes, and diabetes mellitus categories and positively correlated with all dysglycemic profiles (all p<0.001). Multi-variate logistic and linear regression models demonstrated independent associations between greater TAC density and all dysglycemic indices (Coef: 2.5, 1.4, 6.8 for fasting, postprandial sugar and HbA1c) and diabetes mellitus status (all p<0.05). Furthermore, Receiver-operating characteristic curves (ROC) showed fasting sugar and postprandial sugar set at 103mg/dL and 111mg/dL, separately, with HbA1c set at 5.8% all predict the presence of aortic calcification. Dysglycemic status, even without overt diabetes mellitus, were tighly linked to subclinical, pathological thoracic aortic calcification.
url https://doi.org/10.1371/journal.pone.0207089
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