Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.
Thoracic aortic calcification (TAC) is tightly linked to pathological atherosclerosis and associated with certain cardiovascular diseases. While diabetes mellitus (DM) is known as a coronary heart disease equivalent, we examined the presence of TAC across the dysglycemic spectrum of diabetes mellitu...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0207089 |
id |
doaj-c06529a0f4514b4c947ce40be303c420 |
---|---|
record_format |
Article |
spelling |
doaj-c06529a0f4514b4c947ce40be303c4202021-03-03T20:59:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01141e020708910.1371/journal.pone.0207089Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms.Jui-Peng TsaiRichard KuoJing-Yi SunChun-Ho YunKuo-Tze SungChuan-Chuan LiuJen-Yuan KuoChung-Lieh HungTung-Hsin WuJiun-Lu LinTa-Chuan HungChia-Yuan LiuCharles Jia-Yin HouHung-I YehHiram G BezerraThoracic aortic calcification (TAC) is tightly linked to pathological atherosclerosis and associated with certain cardiovascular diseases. While diabetes mellitus (DM) is known as a coronary heart disease equivalent, we examined the presence of TAC across the dysglycemic spectrum of diabetes mellitus (DM). We consecutively studied 3003 asymptomatic ethnic Asians underwent annual cardiovacular health survey, and further categorized them into: 1) 1760 normo-glycemic, 2) 968 pre-diabetic, and 3) 274 overt DM based on dysglycemic indices and medical histories. Several TAC parameters were assessed using non-contrast multi-detector computed tomography (MDCT), and related to dysglycemic indices or diabetes mellitus status. A remarkably graded increases of adjusted total TAC calcium burden, volume and density were seen across Non-diabetes, Pre-diabetes, and diabetes mellitus categories and positively correlated with all dysglycemic profiles (all p<0.001). Multi-variate logistic and linear regression models demonstrated independent associations between greater TAC density and all dysglycemic indices (Coef: 2.5, 1.4, 6.8 for fasting, postprandial sugar and HbA1c) and diabetes mellitus status (all p<0.05). Furthermore, Receiver-operating characteristic curves (ROC) showed fasting sugar and postprandial sugar set at 103mg/dL and 111mg/dL, separately, with HbA1c set at 5.8% all predict the presence of aortic calcification. Dysglycemic status, even without overt diabetes mellitus, were tighly linked to subclinical, pathological thoracic aortic calcification.https://doi.org/10.1371/journal.pone.0207089 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jui-Peng Tsai Richard Kuo Jing-Yi Sun Chun-Ho Yun Kuo-Tze Sung Chuan-Chuan Liu Jen-Yuan Kuo Chung-Lieh Hung Tung-Hsin Wu Jiun-Lu Lin Ta-Chuan Hung Chia-Yuan Liu Charles Jia-Yin Hou Hung-I Yeh Hiram G Bezerra |
spellingShingle |
Jui-Peng Tsai Richard Kuo Jing-Yi Sun Chun-Ho Yun Kuo-Tze Sung Chuan-Chuan Liu Jen-Yuan Kuo Chung-Lieh Hung Tung-Hsin Wu Jiun-Lu Lin Ta-Chuan Hung Chia-Yuan Liu Charles Jia-Yin Hou Hung-I Yeh Hiram G Bezerra Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms. PLoS ONE |
author_facet |
Jui-Peng Tsai Richard Kuo Jing-Yi Sun Chun-Ho Yun Kuo-Tze Sung Chuan-Chuan Liu Jen-Yuan Kuo Chung-Lieh Hung Tung-Hsin Wu Jiun-Lu Lin Ta-Chuan Hung Chia-Yuan Liu Charles Jia-Yin Hou Hung-I Yeh Hiram G Bezerra |
author_sort |
Jui-Peng Tsai |
title |
Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms. |
title_short |
Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms. |
title_full |
Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms. |
title_fullStr |
Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms. |
title_full_unstemmed |
Thoracic aortic calcification across the clinical dysglycemic continuum in a large Asian population free of cardiovascular symptoms. |
title_sort |
thoracic aortic calcification across the clinical dysglycemic continuum in a large asian population free of cardiovascular symptoms. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
Thoracic aortic calcification (TAC) is tightly linked to pathological atherosclerosis and associated with certain cardiovascular diseases. While diabetes mellitus (DM) is known as a coronary heart disease equivalent, we examined the presence of TAC across the dysglycemic spectrum of diabetes mellitus (DM). We consecutively studied 3003 asymptomatic ethnic Asians underwent annual cardiovacular health survey, and further categorized them into: 1) 1760 normo-glycemic, 2) 968 pre-diabetic, and 3) 274 overt DM based on dysglycemic indices and medical histories. Several TAC parameters were assessed using non-contrast multi-detector computed tomography (MDCT), and related to dysglycemic indices or diabetes mellitus status. A remarkably graded increases of adjusted total TAC calcium burden, volume and density were seen across Non-diabetes, Pre-diabetes, and diabetes mellitus categories and positively correlated with all dysglycemic profiles (all p<0.001). Multi-variate logistic and linear regression models demonstrated independent associations between greater TAC density and all dysglycemic indices (Coef: 2.5, 1.4, 6.8 for fasting, postprandial sugar and HbA1c) and diabetes mellitus status (all p<0.05). Furthermore, Receiver-operating characteristic curves (ROC) showed fasting sugar and postprandial sugar set at 103mg/dL and 111mg/dL, separately, with HbA1c set at 5.8% all predict the presence of aortic calcification. Dysglycemic status, even without overt diabetes mellitus, were tighly linked to subclinical, pathological thoracic aortic calcification. |
url |
https://doi.org/10.1371/journal.pone.0207089 |
work_keys_str_mv |
AT juipengtsai thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT richardkuo thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT jingyisun thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT chunhoyun thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT kuotzesung thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT chuanchuanliu thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT jenyuankuo thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT chungliehhung thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT tunghsinwu thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT jiunlulin thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT tachuanhung thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT chiayuanliu thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT charlesjiayinhou thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT hungiyeh thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms AT hiramgbezerra thoracicaorticcalcificationacrosstheclinicaldysglycemiccontinuuminalargeasianpopulationfreeofcardiovascularsymptoms |
_version_ |
1714819442657984512 |