A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy.

A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy.

Leprosy Type-1 Reactions (T1Rs) are pathological inflammatory responses that afflict a sub-group of leprosy patients and result in peripheral nerve damage. Here, we employed a family-based GWAS in 221 families with 229 T1R-affect offspring with stepwise replication to identify risk factors for T1R....

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Bibliographic Details
Main Authors: Vinicius M Fava, Jeremy Manry, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Milton O Moraes, Carolinne Sales-Marques, Mariane M A Stefani, Ana Carla P Latini, Andrea F Belone, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin Schurr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5340414?pdf=render

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