Liver Illness and Psoriatic Patients

Liver Illness and Psoriatic Patients

Psoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world’s population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated and a...

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Main Authors: Marco Fiore, Sebastiano Leone, Alberto Enrico Maraolo, Emilio Berti, Giovanni Damiani
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/3140983
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spelling doaj-c048b556e867441dbdfd74190277d3002020-11-24T21:35:01ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/31409833140983Liver Illness and Psoriatic PatientsMarco Fiore0Sebastiano Leone1Alberto Enrico Maraolo2Emilio Berti3Giovanni Damiani4Department of Anaesthesiological, Surgical and Emergency Sciences, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medicine, Division of Infectious Diseases, “San Giuseppe Moscati” Hospital, Avellino, ItalyDepartment of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, Naples, ItalyDepartment of Pathophysiology and Transplantation, Dermatology Unit, IRCCS Ca' Granda, University of Milan, Milan, ItalyDepartment of Pathophysiology and Transplantation, Dermatology Unit, IRCCS Ca' Granda, University of Milan, Milan, ItalyPsoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world’s population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated and a direct liver injury; therefore, treatment of patients with psoriasis poses a therapeutic challenge. The aim of this minireview is to help clinicians in the management of psoriatic patients who develop signs of liver dysfunction. To find relevant articles, a comprehensive search was performed on PubMed, EMBASE, and Cochrane with appropriate combinations of the following keywords being considered: viral hepatitis, nonalcoholic fatty liver disease, psoriasis, hepatotoxicity, drug toxicity, cholestasis, and autoimmune liver diseases.http://dx.doi.org/10.1155/2018/3140983
collection DOAJ
language English
format Article
sources DOAJ
author Marco Fiore
Sebastiano Leone
Alberto Enrico Maraolo
Emilio Berti
Giovanni Damiani
spellingShingle Marco Fiore
Sebastiano Leone
Alberto Enrico Maraolo
Emilio Berti
Giovanni Damiani
Liver Illness and Psoriatic Patients
BioMed Research International
author_facet Marco Fiore
Sebastiano Leone
Alberto Enrico Maraolo
Emilio Berti
Giovanni Damiani
author_sort Marco Fiore
title Liver Illness and Psoriatic Patients
title_short Liver Illness and Psoriatic Patients
title_full Liver Illness and Psoriatic Patients
title_fullStr Liver Illness and Psoriatic Patients
title_full_unstemmed Liver Illness and Psoriatic Patients
title_sort liver illness and psoriatic patients
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2018-01-01
description Psoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world’s population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated and a direct liver injury; therefore, treatment of patients with psoriasis poses a therapeutic challenge. The aim of this minireview is to help clinicians in the management of psoriatic patients who develop signs of liver dysfunction. To find relevant articles, a comprehensive search was performed on PubMed, EMBASE, and Cochrane with appropriate combinations of the following keywords being considered: viral hepatitis, nonalcoholic fatty liver disease, psoriasis, hepatotoxicity, drug toxicity, cholestasis, and autoimmune liver diseases.
url http://dx.doi.org/10.1155/2018/3140983
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AT sebastianoleone liverillnessandpsoriaticpatients
AT albertoenricomaraolo liverillnessandpsoriaticpatients
AT emilioberti liverillnessandpsoriaticpatients
AT giovannidamiani liverillnessandpsoriaticpatients
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