β-Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPARγ/NF-κB Signalling

β-Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPARγ/NF-κB Signalling

Myocardial ischemia/reperfusion (I/R) injury is a clinically severe complication, which can cause high rates of disability and mortality particularly in patients with myocardial infarction, yet the molecular mechanisms underlying this process remain unclear. This study aimed to explore the protectiv...

Full description

Bibliographic Details
Main Authors:	Fengxia Lin, Luhua Xu, Meizhu Huang, Bin Deng, Weiwei Zhang, Zhicong Zeng, Song Yinzhi
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2020/2679409

Similar Items

PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation
by: Bo Xie, et al.
Published: (2018-11-01)

Mangiferin Mitigates Gastric Ulcer in Ischemia/ Reperfused Rats: Involvement of PPAR-γ, NF-κB and Nrf2/HO-1 Signaling Pathways.
by: Magdy Mahmoud-Awny, et al.
Published: (2015-01-01)

PPARγ in Ischemia-Reperfusion Injury: Overview of the Biology and Therapy
by: Ruizhen Huang, et al.
Published: (2021-04-01)

N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury.
by: Jessica Zúñiga, et al.
Published: (2011-01-01)

Roles of PPARγ/NF-κB signaling pathway in the pathogenesis of intrahepatic cholestasis of pregnancy.
by: Yan Zhang, et al.
Published: (2014-01-01)

Regulation of NF-κB activation by PPARγ in mice with meningoencephalitis caused by Angiostrongylus cantonensis
by: Chi-Yang, et al.
Published: (2011)

β-Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling
by: Sara Kasirzadeh, et al.
Published: (2021-01-01)

Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds
by: E. Rozema, et al.
Published: (2012-01-01)

PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production
by: Chaoqun Wang, et al.
Published: (2021-01-01)

Ginkgolide C Alleviates Myocardial Ischemia/Reperfusion-Induced Inflammatory Injury via Inhibition of CD40-NF-κB Pathway
by: Rui Zhang, et al.
Published: (2018-02-01)

Cardioprotection of Ginkgolide B on Myocardial Ischemia/Reperfusion-Induced Inflammatory Injury via Regulation of A20-NF-κB Pathway
by: Rui Zhang, et al.
Published: (2018-12-01)

Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo
by: Kun Liu, et al.
Published: (2019-01-01)

PPAR γ/Nnat/NF-κB Axis Involved in Promoting Effects of Adiponectin on Preadipocyte Differentiation
by: Wenkai Yang, et al.
Published: (2019-01-01)

microRNA-130a-5p suppresses myocardial ischemia reperfusion injury by downregulating the HMGB2/NF-κB axis
by: Yong Li, et al.
Published: (2021-03-01)

Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway
by: Kun Liu, et al.
Published: (2019-01-01)

Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7/NF-κB Pathway
by: Meng Gu, et al.
Published: (2016-01-01)

β-caryophyllene improves cerebral ischemia reperfusion injury in rats via Notch1/NF-κB signal axis
by: LIU Jingdong, et al.
Published: (2021-02-01)

Influence of Rosiglitazone on the Expression of PPARγ, NF-κB, and TNF-α in Rat Model of Ulcerative Colitis
by: Jing-Wei Mao, et al.
Published: (2012-01-01)

PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway
by: Liwei Wu, et al.
Published: (2021-01-01)

The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
by: M. Elias-Miró, et al.
Published: (2012-01-01)

Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways
by: Maged E. Mohamed, et al.
Published: (2021-04-01)

Protective effects of pterostilbene on ulcerative colitis in rats via suppressing NF-κB pathway and activating PPAR-γ
by: Liu Shi, et al.
Published: (2019-03-01)

Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway
by: Yongbing Deng, et al.
Published: (2020-06-01)

Effect of heat shock preconditioning on NF-κB/I-κB pathway during ischemia-reperfusion injury of the rat liver
by: Uchinami, Hiroshi
Published: (2011)

Role of cytokines in myocardial ischemia and reperfusion
by: H. S. Sharma, et al.
Published: (1997-01-01)

Gene therapy in myocardial ischemia-reperfusion
by: Abunasra, Haitham Juma
Published: (2004)

Chelerythrine Attenuates Renal Ischemia/Reperfusion-induced Myocardial Injury by Activating CSE/H2S via PKC/NF-κB Pathway in Diabetic Rats
by: Bo Hu, et al.
Published: (2017-06-01)

Alpha linolenic acid intake alleviates myocardial ischemia/reperfusion injury via the P2X7R/NF-κB signalling pathway
by: Shuo Wang, et al.
Published: (2018-10-01)

Beneficial Effects of THSG on Acetic Acid-Induced Experimental Colitis: Involvement of Upregulation of PPAR-γ and Inhibition of the Nf-Κb Inflammatory Pathway
by: Jia-Ling Wang, et al.
Published: (2011-10-01)

Mechanisms of myocardial ischemia-reperfusion injury in diabetic ratMechanisms of myocardial ischemia-reperfusion injury in diabetic rat
by: Jiung-Pang Huang, et al.
Published: (2006)

PPARβ/δ Is Required for Mesenchymal Stem Cell Cardioprotective Effects Independently of Their Anti-inflammatory Properties in Myocardial Ischemia-Reperfusion Injury
by: Nitirut Nernpermpisooth, et al.
Published: (2021-09-01)

Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via Inhibition of NF-κB Activation and Inflammation in Rats
by: Gaode Zou, et al.
Published: (2021-07-01)

Vildagliptin Attenuates Hepatic Ischemia/Reperfusion Injury via the TLR4/NF-κB Signaling Pathway
by: Iman O. Sherif, et al.
Published: (2018-01-01)

Febuxostat Modulates MAPK/NF-κBp65/TNF-α Signaling in Cardiac Ischemia-Reperfusion Injury
by: Sana Irfan Khan, et al.
Published: (2017-01-01)

An Algal Metabolite-Based PPAR-γ Agonist Displayed Anti-Inflammatory Effect via Inhibition of the NF-κB Pathway
by: Zhiran Ju, et al.
Published: (2019-05-01)

CD97/ADGRE5 Inhibits LPS Induced NF-κB Activation through PPAR-γ Upregulation in Macrophages
by: Shuai Wang, et al.
Published: (2016-01-01)

PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice
by: Jinying Wei, et al.
Published: (2021-01-01)

Protectin D1 alleviates cardiac ischemia-reperfusion injury in rats by up-regulating GPR37/JNK/PPAR-γ signaling pathway in cardiac macrophages
by: ZENG Yalin, et al.
Published: (2019-08-01)

Acidic Microenvironment Aggravates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating M1-Polarization Through Regulating PPAR-γ Signal
by: Wei Ding, et al.
Published: (2021-06-01)

Long non-coding RNA-ROR aggravates myocardial ischemia/reperfusion injury
by: Weiwei Zhang, et al.
Published: (2018-04-01)