Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines

• Main Authors: Maria Fuertes, Carme Masdeu, Endika Martin-Encinas, Asier Selas, Gloria Rubiales, Francisco Palacios, Concepcion Alonso
• Format: Article
• Language: English
• Published: MDPI AG 2020-07-01
• Series: Molecules
• Subjects: 1,5-naphthyridines; heterocycle synthesis; metal complexes; biological activity
• Online Access: https://www.mdpi.com/1420-3049/25/14/3252

This review covers the synthesis and reactivity of 1,5-naphthyridine derivatives published in the last 18 years. These heterocycles present a significant importance in the field of medicinal chemistry because many of them exhibit a great variety of biological activities. First, the published strategies related to the synthesis of 1,5-naphthyridines are presented followed by the reactivity of these compounds with electrophilic or nucleophilic reagents, in oxidations, reductions, cross-coupling reactions, modification of side chains or formation of metal complexes. Finally, some properties and applications of these heterocycles studied during this period are examined.