Reduced Annexin A1 Secretion by ABCA1 Causes Retinal Inflammation and Ganglion Cell Apoptosis in a Murine Glaucoma Model

Reduced Annexin A1 Secretion by ABCA1 Causes Retinal Inflammation and Ganglion Cell Apoptosis in a Murine Glaucoma Model

Variants near the ATP-binding cassette transporter A1 (ABCA1) gene are associated with elevated intraocular pressure and newly discovered risk factors for glaucoma. Previous studies have shown an association between ABCA1 deficiency and retinal inflammation. Using a mouse model of ischemia-reperfusi...

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Bibliographic Details
Main Authors: Lu Li, Lingjuan Xu, Wei Chen, Xing Li, Qian Xia, Lu Zheng, Qiming Duan, Hong Zhang, Yin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
retina
ischemia/reperfusion injury
retinal ganglion cells (RGCs)
ABCA1
annexin A1
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00347/full

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