Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases.

Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases.

The remodeling process in bone yields numerous cytokines and chemokines that mediate crosstalk between osteoblasts and osteoclasts and also serve to attract and support metastatic tumor cells. The metastatic tumor cells disturb the equilibrium in bone that manifests as skeletal complications. The He...

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Bibliographic Details
Main Authors: Shamik Das, J Allan Tucker, Shikha Khullar, Rajeev S Samant, Lalita A Shevde
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3315536?pdf=render

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