In vitro inhibition of porcine reproductive and respiratory syndrome virus replication by short antisense oligonucleotides with locked nucleic acid modification

In vitro inhibition of porcine reproductive and respiratory syndrome virus replication by short antisense oligonucleotides with locked nucleic acid modification

Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) causes porcine reproductive and respiratory syndrome (PRRS), which is currently insufficiently controlled. From a previous small-scale screen we identified an effective DNA-based short antisense oligonucleotide (AS-ON) t...

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Bibliographic Details
Main Authors: Lingyun Zhu, Junlong Bi, Longlong Zheng, Qian Zhao, Xianghua Shu, Gang Guo, Jia Liu, Guishu Yang, Jianping Liu, Gefen Yin
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Veterinary Research
Subjects:
Porcine reproductive and respiratory syndrome virus (PRRSV)
Locked nucleic acids (LNAs)
Virus replication
Antisense oligonucleotides
Marc-145
Pulmonary alveolar macrophages (PAMs)
Online Access:http://link.springer.com/article/10.1186/s12917-018-1432-1

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