Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13049 |
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doaj-c0190224ff2c4b5b97ae064cba887a7a2021-05-11T11:01:33ZengNature Publishing GroupNature Communications2041-17232016-10-017111210.1038/ncomms13049Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genesAnirban Chakraborty0Nisha Tapryal1Tatiana Venkova2Nobuo Horikoshi3Raj K. Pandita4Altaf H. Sarker5Partha S. Sarkar6Tej K. Pandita7Tapas K. Hazra8Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Sealy Center for Molecular Medicine, University of Texas Medical BranchDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Sealy Center for Molecular Medicine, University of Texas Medical BranchDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Sealy Center for Molecular Medicine, University of Texas Medical BranchDepartment of Radiation Oncology, The Houston Methodist Research InstituteDepartment of Radiation Oncology, The Houston Methodist Research InstituteDivision of Life Sciences, Department of Cancer and DNA Damage Responses, Lawrence Berkeley National LaboratoryDepartment of Neurology and Neuroscience and Cell Biology, University of Texas Medical BranchDepartment of Radiation Oncology, The Houston Methodist Research InstituteDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Sealy Center for Molecular Medicine, University of Texas Medical BranchMost adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.https://doi.org/10.1038/ncomms13049 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Anirban Chakraborty Nisha Tapryal Tatiana Venkova Nobuo Horikoshi Raj K. Pandita Altaf H. Sarker Partha S. Sarkar Tej K. Pandita Tapas K. Hazra |
| spellingShingle |
Anirban Chakraborty Nisha Tapryal Tatiana Venkova Nobuo Horikoshi Raj K. Pandita Altaf H. Sarker Partha S. Sarkar Tej K. Pandita Tapas K. Hazra Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes Nature Communications |
| author_facet |
Anirban Chakraborty Nisha Tapryal Tatiana Venkova Nobuo Horikoshi Raj K. Pandita Altaf H. Sarker Partha S. Sarkar Tej K. Pandita Tapas K. Hazra |
| author_sort |
Anirban Chakraborty |
| title |
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes |
| title_short |
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes |
| title_full |
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes |
| title_fullStr |
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes |
| title_full_unstemmed |
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes |
| title_sort |
classical non-homologous end-joining pathway utilizes nascent rna for error-free double-strand break repair of transcribed genes |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-10-01 |
| description |
Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair. |
| url |
https://doi.org/10.1038/ncomms13049 |
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