Clinical features of nervous system disorders in patients with EBV as monoinfection and in association with other herpes viruses in their reactivation and persistence

• Main Authors: A.O. Rudenko, L.V. Muravska, P.A. Dyachenko, B.A. Parkhomets, V.Yu. Klyus
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2017-11-01
• Series: Aktualʹnaâ Infektologiâ
• Subjects: Epstein — Barr virus; reactivation; persistence; nervous system disorders; clinical syndromes
• Online Access: http://ai.zaslavsky.com.ua/article/view/122136
• ISSN: 2312-413X; 2312-4148

We have examined 48 patients with nervous system disorders caused by Epstein — Barr virus (EBV) as monoinfection or in association with other herpes viruses during their reactivation (n = 34) or persistence (n = 14). With the activation of Epstein — Barr virus infection, arachnoiditis is most often diagnosed — 29.4 %, as well as arachnoencephalitis — 26.5 %, rarely — disseminated encephalomyelitis (DEM) — 11.8 % and encephalitis 11.8 %, encephalopolyneuropathy — 5.9 %, meningoencephalitis — 5.9 %. With persistence of herpes viruses, encephalitis was not detected, arachnoiditis was diagnosed in 28.6 % of patients, arachnoencephalitis — in 28.6 %, and DEM — in 14.3 %. Differences in the detection of neurologic symptoms and syndromes in the group of patients with activation and reactivation are shown as compared with persistence.