Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild...

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Bibliographic Details
Main Authors: Denisa Leonte, László Csaba Bencze, Csaba Paizs, Florin Dan Irimie, Valentin Zaharia
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Molecules
Subjects:
Mannich reaction
heterocyclic compounds
lipase
biocatalytic promiscuity
Online Access:http://www.mdpi.com/1420-3049/20/7/12300

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