Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild...
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MDPI AG
2015-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/7/12300 |
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doaj-c00ba71aff604fc681589d4e0250ef182020-11-24T22:54:33ZengMDPI AGMolecules1420-30492015-07-01207123001231310.3390/molecules200712300molecules200712300Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and DerivativesDenisa Leonte0László Csaba Bencze1Csaba Paizs2Florin Dan Irimie3Valentin Zaharia4Department of Organic Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş street, RO-400012 Cluj-Napoca, RomaniaDepartment of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, RomaniaDepartment of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, RomaniaDepartment of Biochemistry and Biochemical Engineering, Babeş-Bolyai University of Cluj-Napoca, 11 Arany János street, RO-400028 Cluj-Napoca, RomaniaDepartment of Organic Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş street, RO-400012 Cluj-Napoca, RomaniaThis paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry.http://www.mdpi.com/1420-3049/20/7/12300Mannich reactionheterocyclic compoundslipasebiocatalytic promiscuity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Denisa Leonte László Csaba Bencze Csaba Paizs Florin Dan Irimie Valentin Zaharia |
| spellingShingle |
Denisa Leonte László Csaba Bencze Csaba Paizs Florin Dan Irimie Valentin Zaharia Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives Molecules Mannich reaction heterocyclic compounds lipase biocatalytic promiscuity |
| author_facet |
Denisa Leonte László Csaba Bencze Csaba Paizs Florin Dan Irimie Valentin Zaharia |
| author_sort |
Denisa Leonte |
| title |
Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives |
| title_short |
Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives |
| title_full |
Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives |
| title_fullStr |
Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives |
| title_full_unstemmed |
Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives |
| title_sort |
heterocycles 38. biocatalytic synthesis of new heterocyclic mannich bases and derivatives |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2015-07-01 |
| description |
This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry. |
| topic |
Mannich reaction heterocyclic compounds lipase biocatalytic promiscuity |
| url |
http://www.mdpi.com/1420-3049/20/7/12300 |
| work_keys_str_mv |
AT denisaleonte heterocycles38biocatalyticsynthesisofnewheterocyclicmannichbasesandderivatives AT laszlocsababencze heterocycles38biocatalyticsynthesisofnewheterocyclicmannichbasesandderivatives AT csabapaizs heterocycles38biocatalyticsynthesisofnewheterocyclicmannichbasesandderivatives AT florindanirimie heterocycles38biocatalyticsynthesisofnewheterocyclicmannichbasesandderivatives AT valentinzaharia heterocycles38biocatalyticsynthesisofnewheterocyclicmannichbasesandderivatives |
| _version_ |
1725659152334716928 |