DETERMINATION OF DOXORUBICIN HYDROCHLORIDE IN PHARMACEUTICA DOSAGE FORMS BY A SIMPLE STABILITY-INDICATING MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY METHOD

DETERMINATION OF DOXORUBICIN HYDROCHLORIDE IN PHARMACEUTICA DOSAGE FORMS BY A SIMPLE STABILITY-INDICATING MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY METHOD

A stability-indicating micellar electrokinetic capillary chromatography (MEKC) method was developed and validated for the analysis of doxorubicin hydrochloride in injectable pharmaceutical dosage forms, using methotrexate as internal standard. A fused-silica capillary (50 µm i.d.; effective length,...

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Bibliographic Details
Main Authors: Daniele Rubert Nogueira-Librelotto, Laís Engroff Scheeren, Clarice Madalena Bueno Rolim, Letícia Bueno Macedo, Joana Rodrigues Fernandes
Format: Article
Language:English
Published: Universidade Federal do Rio Grande do Sul 2019-07-01
Series:Drug Analytical Research
Subjects:
method validation
forced degradation studies
factorial design
drug quality control
uv detection
Online Access:https://seer.ufrgs.br/dar/article/view/91896/53385

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