Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus

Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus

Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced genes in Burkitt lymphoma cells.

Bibliographic Details
Main Authors: Kyoung-Dong Kim, Hideki Tanizawa, Alessandra De Leo, Olga Vladimirova, Andrew Kossenkov, Fang Lu, Louise C. Showe, Ken-ichi Noma, Paul M. Lieberman
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14152-8

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