Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death

Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properti...

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Main Authors:	K. Hayashi, F. Nikolos, Y. C. Lee, A. Jain, E. Tsouko, H. Gao, A. Kasabyan, H. E. Leung, A. Osipov, S. Y. Jung, A. V. Kurtova, K. S. Chan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19970-9

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spelling	doaj-bfe5d024758a491d9f637bb1c65371372021-01-31T13:45:10ZengNature Publishing GroupNature Communications2041-17232020-12-0111111310.1038/s41467-020-19970-9Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell deathK. Hayashi0F. Nikolos1Y. C. Lee2A. Jain3E. Tsouko4H. Gao5A. Kasabyan6H. E. Leung7A. Osipov8S. Y. Jung9A. V. Kurtova10K. S. Chan11Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical CenterSamuel Oschin Cancer Center, Cedars-Sinai Medical CenterGraduate Institute of Medical Sciences, Taipei Medical UniversityAlkek Center for Molecular Discovery, Proteomics Core, Baylor College of MedicineDepartment of Orthopedic Surgery, Baylor College of MedicineSamuel Oschin Cancer Center, Cedars-Sinai Medical CenterSamuel Oschin Cancer Center, Cedars-Sinai Medical CenterAlkek Center for Molecular Discovery, Proteomics Core, Baylor College of MedicineSamuel Oschin Cancer Center, Cedars-Sinai Medical CenterAlkek Center for Molecular Discovery, Proteomics Core, Baylor College of MedicineGraduate Program in Translational Biology and Molecular Medicine, Baylor College of MedicineDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical CenterMost chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE2.https://doi.org/10.1038/s41467-020-19970-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	K. Hayashi F. Nikolos Y. C. Lee A. Jain E. Tsouko H. Gao A. Kasabyan H. E. Leung A. Osipov S. Y. Jung A. V. Kurtova K. S. Chan
spellingShingle	K. Hayashi F. Nikolos Y. C. Lee A. Jain E. Tsouko H. Gao A. Kasabyan H. E. Leung A. Osipov S. Y. Jung A. V. Kurtova K. S. Chan Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death Nature Communications
author_facet	K. Hayashi F. Nikolos Y. C. Lee A. Jain E. Tsouko H. Gao A. Kasabyan H. E. Leung A. Osipov S. Y. Jung A. V. Kurtova K. S. Chan
author_sort	K. Hayashi
title	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_short	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_full	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_fullStr	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_full_unstemmed	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_sort	tipping the immunostimulatory and inhibitory damp balance to harness immunogenic cell death
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-12-01
description	Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE2.
url	https://doi.org/10.1038/s41467-020-19970-9
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Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death

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