Levels of vitamin D, sex hormones and erectile function in young and middle-aged men

• Main Authors: V.O. Bondarenko, O.О. Khyzhnyak, A.S. Minukhin, E.I. Skornyakov, O.G. Dorosh, R.S. Nikolaev, E.M. Sanina
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2020-08-01
• Series: Mìžnarodnij Endokrinologìčnij Žurnal
• Subjects: vitamin d; erectile function; estradiol; testosterone; diabetes mellitus type 2
• Online Access: http://iej.zaslavsky.com.ua/article/view/212741
• ISSN: 2224-0721; 2307-1427

Background. Erectile dysfunction in men with vitamin D deficiency is associated with a decrease in testosterone levels in the blood. At the same time, in modern studies there is no data on the state of erectile function depending on changes in the relative androgenization-testosterone/estradiol ratio in terms of vitamin D deficiency and insufficiency. There are no comparative data on the state of erectile dysfunction in young and middle-aged men, especially in the presence and absence of type 2 diabetes mellitus (DM2). The purpose: to determine the features of erectile function changes in young and middle-aged men, depending on the androgenic state and the blood levels of 25-hydroxycholecalci­ferol (25(ОН)D). Materials and methods. Forty-seven males aged 23–59 years were divided into three groups: group 1 (n = 20) — young men (32.3 ± 1.1 years); group 2 (n = 15) — middle-aged men (53.0 ± 1.0 years) without DM2; group 3 (n = 12) — middle-aged men (54.0 ± 1.1 years) with DM2. Using immunoassay commercial kits, blood content of 25(ОН)D (ELISA, Germany), total testosterone (Alkor-Bio) and estradiol (DRG) were measured.The state of erectile function was determined using the International Index of Erectile Function. The studies were carried out in the autumn-winter period of 2019–2020. Results. It was found that the blood levels of 25(ОН)D in middle-aged men, regardless of the presence or absence of DM2, were significantly lower than that of men in group 1. It was proved that formation of erectile dysfunction in both young and middle-aged men is caused by a decrease in testosterone levels and in testosterone/estradiol ratio. Conclusion. It was found that the reduction of 25(ОН)D blood levels can be a predictor of hypotestosteronemia and androgen-estrogen balance disorders in men irrespective of age, in particular in patients with DM2.