M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1...

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Bibliographic Details
Main Authors: Indira Bag, Shue Chen, Leah F. Rosin, Yang Chen, Chen-Yu Liu, Guo-Yun Yu, Elissa P. Lei
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24407-y
Description
Summary:Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.
ISSN:2041-1723

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