High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma.

High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma.

Drug repurposing or repositioning is an important part of drug discovery that has been growing in the last few years for the development of therapeutic options in oncology. We applied this paradigm in a screening of a library of about 3,800 compounds (including FDA-approved drugs and pharmacological...

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Main Authors: Alessio Giubellino, Uma Shankavaram, Petra Bullova, Jan Schovanek, Yaqin Zhang, Min Shen, Nikita Patel, Abdel Elkahloun, Min-Jung Lee, Jane Trepel, Marc Ferrer, Karel Pacak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3974653?pdf=render

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