Phenotypic analysis of catastrophic childhood epilepsy genes
Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays. Their study provides a useful resource for the...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-06-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02221-y |
| id |
doaj-bfcda728977044beb624cc6204edc73f |
|---|---|
| record_format |
Article |
| spelling |
doaj-bfcda728977044beb624cc6204edc73f2021-06-06T11:30:38ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111310.1038/s42003-021-02221-yPhenotypic analysis of catastrophic childhood epilepsy genesAliesha Griffin0Colleen Carpenter1Jing Liu2Rosalia Paterno3Brian Grone4Kyla Hamling5Maia Moog6Matthew T. Dinday7Francisco Figueroa8Mana Anvar9Chinwendu Ononuju10Tony Qu11Scott C. Baraban12Epilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoHelen Wills Neuroscience Institute, University of CaliforniaHelen Wills Neuroscience Institute, University of CaliforniaEpilepsy Research Laboratory and Weill Institute for Neuroscience, Department of Neurological Surgery, University of California San FranciscoGriffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays. Their study provides a useful resource for the future functional analysis and/or identification of potential anti-epileptic therapies.https://doi.org/10.1038/s42003-021-02221-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aliesha Griffin Colleen Carpenter Jing Liu Rosalia Paterno Brian Grone Kyla Hamling Maia Moog Matthew T. Dinday Francisco Figueroa Mana Anvar Chinwendu Ononuju Tony Qu Scott C. Baraban |
| spellingShingle |
Aliesha Griffin Colleen Carpenter Jing Liu Rosalia Paterno Brian Grone Kyla Hamling Maia Moog Matthew T. Dinday Francisco Figueroa Mana Anvar Chinwendu Ononuju Tony Qu Scott C. Baraban Phenotypic analysis of catastrophic childhood epilepsy genes Communications Biology |
| author_facet |
Aliesha Griffin Colleen Carpenter Jing Liu Rosalia Paterno Brian Grone Kyla Hamling Maia Moog Matthew T. Dinday Francisco Figueroa Mana Anvar Chinwendu Ononuju Tony Qu Scott C. Baraban |
| author_sort |
Aliesha Griffin |
| title |
Phenotypic analysis of catastrophic childhood epilepsy genes |
| title_short |
Phenotypic analysis of catastrophic childhood epilepsy genes |
| title_full |
Phenotypic analysis of catastrophic childhood epilepsy genes |
| title_fullStr |
Phenotypic analysis of catastrophic childhood epilepsy genes |
| title_full_unstemmed |
Phenotypic analysis of catastrophic childhood epilepsy genes |
| title_sort |
phenotypic analysis of catastrophic childhood epilepsy genes |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-06-01 |
| description |
Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays. Their study provides a useful resource for the future functional analysis and/or identification of potential anti-epileptic therapies. |
| url |
https://doi.org/10.1038/s42003-021-02221-y |
| work_keys_str_mv |
AT alieshagriffin phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT colleencarpenter phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT jingliu phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT rosaliapaterno phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT briangrone phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT kylahamling phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT maiamoog phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT matthewtdinday phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT franciscofigueroa phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT manaanvar phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT chinwenduononuju phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT tonyqu phenotypicanalysisofcatastrophicchildhoodepilepsygenes AT scottcbaraban phenotypicanalysisofcatastrophicchildhoodepilepsygenes |
| _version_ |
1721394003377651712 |