Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties[S]

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties[S]

Cytotoxic bile acids, such as deoxycholic acid (DCA), are responsible for hepatocyte cell death during intrahepatic cholestasis. The mechanisms responsible for this effect are unclear, and recent studies conflict, pointing to either a modulation of plasma membrane structure or mitochondrial-mediated...

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Bibliographic Details
Main Authors: Tânia Sousa, Rui E. Castro, Sandra N. Pinto, Ana Coutinho, Susana D. Lucas, Rui Moreira, Cecília M.P. Rodrigues, Manuel Prieto, Fábio Fernandes
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Lipid Research
Subjects:
apoptosis
bile acids and salts
bile acids and salts/physical chemistry
fluorescence microscopy
membranes/fluidity
membranes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354857

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http://www.sciencedirect.com/science/article/pii/S0022227520354857

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